Case Study 9

The following figure presents blood smear of a woman with a history of pancytopenia and splenomegaly for the last six months. Approximately 35% of her lymphocytes were granular and expressed CD16 and CD56 but were negative for CD3.

1. These lymphocytes represent:

A. Natural killer (NK) cells
B. Cytotoxic T cells
C. Helper T cells
D. Prolymphocytes

2. DND molecular studies may show:

A. Rearranged TCR genes
B. Rearranged Ig genes
C. BCL-2 rearrangement
D. None of the above


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