Mycosis Fungoides/Sezary Syndrome

Major Clinical Features

Elderly patients, usually over 50 years of age

Multiple cutaneous plaques or nodules

Generalized erythroderma

Late event lymphadenopathy

Peripheral blood involvement = Sezary syndrome

Major Morphology (Figure 18 and Figure 19)

Lymphocytes small to large-sized cell with cerebriforn nuclei

Major Immunophenotypic/Molecular Features

Positive: CD2, CD3, CD5, and mostly CD4

Negative: CD7 and CD8 (in the majority of the cases)

TCR gene rearrangement

Selected References

Barcos M: Mycosis fungoides: diagnosis and pathogenesis. Am J Clin Pathol 99: 452, 1993

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