PATHOLOGY 280
Clinical Aspects And Molecular Biology Of Bone Marrow Failure
Winter QUARTER 2011
Course Organizers: Drs. Kathleen Sakamoto and Gary Schiller
Lectures: Mondays from 4:00pm - 5:00pm in Keiter Library (9-240C), 9th floor Factor
Discussions: Thursdays from 4:00pm - 5:00pm in Keiter Library (9-240C), 9th floor Factor
Course materials for each session are located in the portfolios
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Date |
Title |
Files |
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Monday, 1/3 |
NO SESSION
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Portfolio |
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Thursday, 1/6 |
Introduction to Normal Hematopoiesis and Bone Marrow Failure
Ken Dorshkind, Ph.D. and Kathleen Sakamoto, M.D., Ph.D. |
Portfolio
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Monday, 1/10 |
Aplastic Anemia
Ron Paquette, M.D. |
Portfolio
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Thursday, 1/13 |
Journal club
Article
De Latour et al. Th17 immune responses contribute to the pathophysiology of aplastic anemia. Blood 116: 4175-4184, 2010. |
Portfolio |
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Monday, 1/17 |
Martin Luther King Holiday
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Portfolio |
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Thursday, 1/20 |
Diamond Blackfan Anemia
Kenji Morimoto, M.D. |
Portfolio
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Monday, 1/24 |
Dyskeratosis Congenita
Kathy Sakamoto M.D., Ph.D. |
Portfolio
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Thursday, 1/27 |
Journal club
Article
Du H-Y et al. TERC and TERT gene mutations in patients with bone marrow failure and the significance of telomere length measurements. Blood 113:309-316, 2009. (Maria Sierra) |
Portfolio |
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Monday, 1/31 |
Myelodysplastic Syndrome
Mary Territo, M.D.
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Portfolio
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Thursday, 2/3 |
Journal club
Article
Ebert BL et al. Identification of RPS14 as a 5q- syndrome gene by RNA interference screen. Nature 45:335-9, 2008.
Tehranchi et al. Persistent Malignant Stem Cells in del(5q) Myelodysplasia in Remission. N Engl J Med 363:1025-1037 , 2010. |
Portfolio |
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Monday, 2/7 |
Fanconi Anemia
Kenji Morimoto, M.D.
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Portfolio |
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Thursday, 2/10 |
Journal club (Dr. Kenji)
Article
Ge et al. Dyskerin Ablation in Mouse Liver Inhibits rRNA Processing and Cell Division. Mol Cell Biol 30: 413-422, 2010.
Huang M et al. The FANCM/FAAP24 Complex is required for the DNA Interstrand Crosslink-Induced Checkpoint Response. Mol Cell 39: 259-268, 2010. |
Portfolio |
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Monday, 2/14 |
Schwachman Diamond Syndrome
Kathy Sakamoto M.D., Ph.D.
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Portfolio |
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Thursday, 2/17 |
Journal club - CANCELLED
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Portfolio |
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Monday, 2/21 |
Washington’s Birthday Holiday
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Portfolio |
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Thursday, 2/24 |
Paroxysmal Nocturnal Hemoglobinuria
Gary Schiller, M.D. |
Portfolio |
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Monday, 2/28 |
Journal club
Article
Lindorfer et al. A novel approach to preventing the hemolysis of PNH: both complement-mediated cytolysis and C3 deposition are blocked by a monoclonal antibody specific for the alternative pathway of complement. Blood 115: 2283-2291, 2010. (Grace Liu)
Liu et al. FAN1 Acts with FANC1-FANCD2 to Promote DNA Interstrand Cross-Link Repair. Science 329: 693-696, 2010. (Abinav Baweja)
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Portfolio |
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Thursday, 3/3 |
NO SESSION |
Portfolio |
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Monday, 3/7 |
Research methods to study BM failure syndromes
Sophie Song, M.D. and Kathleen Sakamoto, M.D., Ph.D.
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Portfolio |
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Thursday, 3/10 |
Journal club
Article
Westers et al. Aberrant immunophenotype of blasts in MDS is a clinically relevant biomarker in predicting response to growth factor treatment. Blood 115: 1779-1784, 2010. (Justine Walker/Vivian Chang)
Devlin EE et al. A transgenic mouse model demonstrates a dominant negative effect of a point mutation in the RPS19 gene associated with Diamond-Blackfan Anemia. Blood 116: 2826-2835, 2010. (make up journal club, E. Bibikova) |
Portfolio |
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Monday, 3/14 |
FINAL EXAM WEEK BEGINS
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